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  • Title: Theory of force regulation by nascent adhesion sites.
    Author: Bruinsma R.
    Journal: Biophys J; 2005 Jul; 89(1):87-94. PubMed ID: 15849245.
    Abstract:
    The mechanical coupling of a cell with the extracellular matrix relies on adhesion sites, clusters of membrane-associated proteins that communicate forces generated along the F-Actin filaments of the cytoskeleton to connecting tissue. Nascent adhesion sites have been shown to regulate these forces in response to tissue rigidity. Force-regulation by substrate rigidity of adhesion sites with fixed area is not possible for stationary adhesion sites, according to elasticity theory. A simple model is presented to describe force regulation by dynamical adhesion sites.
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