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  • Title: Target accessibility dictates the potency of human RISC.
    Author: Brown KM, Chu CY, Rana TM.
    Journal: Nat Struct Mol Biol; 2005 May; 12(5):469-70. PubMed ID: 15852021.
    Abstract:
    In this report, we examined the effect of increased target site access on activated human RNA-induced silencing complex (RISC(*)) catalysis. Kinetic studies revealed that siRNA-programmed RISC(*) cleaved target RNA with higher efficiencies when target site access was increased. These results provide evidence that target site access is linked to RISC(*) catalysis.
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