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  • Title: Antiproliferative effects of daucane esters from Ferula communis and F. arrigonii on human colon cancer cell lines.
    Author: Poli F, Appendino G, Sacchetti G, Ballero M, Maggiano N, Ranelletti FO.
    Journal: Phytother Res; 2005 Feb; 19(2):152-7. PubMed ID: 15852493.
    Abstract:
    Certain jaesekanadiol p-hydroxy- and p-methoxybenzoates - typical of Ferula communis and Ferula arrigonii sardinian plants - show antiproliferative activity on human colon cancer less. The inhibitory doses 50%, calculated after 72 h of treatment, revealed that the antiproliferative capacity of the compounds was in the following descending order: ferutinin > 2alpha-OH-ferutidin > ferutidin > siol anisate > lapiferin > jaeskeanadiol. Evidence is presented that interaction with type II estrogen-binding sites (EBS) underlies this activity.
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