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  • Title: [Effects of acute hypoxia on expression of heat shock protein 70 in cochlea of guinea pigs].
    Author: Wang HN, Wu W, Wang XJ, Song JS.
    Journal: Space Med Med Eng (Beijing); 2005 Feb; 18(1):25-7. PubMed ID: 15852537.
    Abstract:
    OBJECTIVE: To investigate the changes of the expression of heat shock protein 70 (HSP70) in the cochlea of guinea pigs under acute hypoxia. METHOD: Different degrees of acute hypoxia were imposed on guinea pigs and slices of the cochlea were examined by immunohistochemistry to detect HSP70. RESULT: In normal situation, HSP70 is expressed in guinea pig's cochlea, especially in spiral ganglion and Corti's organ, under acute hypoxia, this expression was strengthened, and the degree of this strengthening showed no correlation with degree of hypoxia. CONCLUSION: These results suggest that acute hypoxia can strengthen the expression of HSP70 in guinea pig's cochlea, and the degree of hypoxia has no effects on the degree of this strengthening. The expression of HSP70 in the cochlea may be a kind of protection to the structure and the function of the inner ear.
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