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  • Title: Nationwide study of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum beta-lactamases in Spain.
    Author: Hernández JR, Martínez-Martínez L, Cantón R, Coque TM, Pascual A, Spanish Group for Nosocomial Infections (GEIH).
    Journal: Antimicrob Agents Chemother; 2005 May; 49(5):2122-5. PubMed ID: 15855544.
    Abstract:
    Clonal dissemination of extended-spectrum beta-lactamases (ESBL) in 170 Escherichia coli isolates and 70 Klebsiella pneumoniae isolates from a nationwide study of 40 Spanish centers in 2000 was not observed in most centers. The most prevalent ESBL were CTX-M-9 (27.3%), SHV-12 (23.9%), and CTX-M-14 (20.5%) for E. coli and TEM-3 (16.7%) and TEM-4 (25%) for K. pneumoniae. A new ESBL, TEM-133, with mutations L21F, E104K, and R164S, was identified.
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