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  • Title: In vitro antileishmanial activity of diphyllin isolated from Haplophyllum bucharicum.
    Author: Di Giorgio C, Delmas F, Akhmedjanova V, Ollivier E, Bessonova I, Riad E, Timon-David P.
    Journal: Planta Med; 2005 Apr; 71(4):366-9. PubMed ID: 15856417.
    Abstract:
    Diphyllin isolated from Haplophyllum bucharicum Litv. (Rutaceae), an endemic plant of Uzbekistan, displayed a moderate antiproliferative activity towards human monocytes (IC50 = 35.2 microM) and Leishmania promastigotes (IC50 = 14.4 microM), by a mechanism of action that involved interaction with macromolecules and resulted in cell cycle arrest in the S-phase and inhibition of protein synthesis. In the intracellular amastigote form of the parasite, diphyllin exerted a strong specific inhibitory activity (IC50 = 0.2 microM) resulting from the inhibition of parasite internalization within macrophages. This property was mainly due to modulation of macrophage phagocytosis and, to a lesser extent, it also involved interference with surface molecules of the promastigote membrane.
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