These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Carbohydrate and lipid metabolism disorders in obese children and adolescents].
    Author: Iwanicka Z, Głab E, Barg E.
    Journal: Med Wieku Rozwoj; 2004; 8(3 Pt 2):815-24. PubMed ID: 15858253.
    Abstract:
    UNLABELLED: THE AIM of the study was to assess the incidence of: 1. insulin resistance, hyperinsulinemia, impaired glucose tolerance and dyslipoproteinemia in serum of obese children according to the type of obesity; 2. family history of obesity, hypertension and type 2 diabetes mellitus. MATERIAL AND METHODS: 177 obese children (M/F 80/97) aged 10-17.5 yrs and 38 normostenic children (control group) were screened for carbohydrate and lipid metabolism disorders. BMI (> or =97 c) and WHR (M/F> or =0.9/0.85 -- abdominal adiposity) were estimated. Glycemia (mmol/l) and insulinemia (microIU/ml) at 0, 30, 60, 90, 120 minutes of OGTT were measured. Fasting C-peptide (ng/ml), HbAlc (%). total cholesterol, LDL-Ch, HDL-Ch, triglycerides (mmol/l), I/G ratio (microIU/ml/mg%) and ChT/HDL-Ch atherogenic index were also investigated. RESULTS: Abdominal adiposity was present in 56.5%. fasting hyperinsulinemia (>20.0 microIU/ml) in 32.2%, insulin resistance (I/G>0.30) in 73.7%; in the group of patients with hyperinsulinemia 66.7% had abdominal adiposity. The glycemia ill OGTT was: normal in 57.0% -- group I; 26.6% did not suit the criteria of normal nor impaired glucose tolerance according to American Diabetes Association (ADA) -- group Ia. The impaired glucose tolerance (IGT) was found in 16.4% -- group II, with fasting hyperinsulinemia in 58.6% and I/G ratio > or =0.30 in 41.3%, HbAlc > 6.2% in 34.5%. Atherogenic lipoproteins levels prevailed (p<0.05) in group Ia and II. The incidence of family history of obesity, hypertension and diabetes mellitus type 2 was higher (statistically not significant, p>0.05) in group Ia and II and significantly higher (p<0.05) in all groups of obese children compared to the control group. CONCLUSION: The results of our study prove that obesity in children is a risk factor for early diabetes mellitus type 2 and atherosclerosis.
    [Abstract] [Full Text] [Related] [New Search]