These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Lung function in immature baboons with respiratory distress syndrome receiving early caffeine therapy: a pilot study.
    Author: Yoder B, Thomson M, Coalson J.
    Journal: Acta Paediatr; 2005 Jan; 94(1):92-8. PubMed ID: 15858967.
    Abstract:
    AIM: The cardiopulmonary effects of early caffeine therapy in surfactant-treated immature baboons were measured. METHODS: Nine 125-d (term = 185 d) baboons receiving caffeine citrate at 1 and 12 h age as part of a pilot study on the use of nasal CPAP at 24 h were compared to six untreated animals destined for prolonged ventilator support. All received surfactant prior to their first breath and again at 6 h age. Serial physiologic and ventilatory parameters were recorded. Lung mechanics were measured by body plethysmography. Data were compared from 1 through 24 h age. RESULTS: There were no between-group differences in any study variables prior to caffeine therapy at 1 h age. Airway resistance (RA) was significantly lower in caffeine-treated compared to non-caffeine-treated animals at 12 and 24 h age [median (range)12 h: 47 (35-107) cm H2O/l/s to 135 (120-259) cm H2O/l/s; and 24 h: 93(60-137) cm H2O/l/s to 211 (86-235) cm H2O/l/s; p < 0.05]. Respiratory system compliance (CRS) was higher in caffeine-treated compared to non-caffeine-treated animals at 18 and 24 h age [median (range) 18 h: 0.60 (0.29-1.58) ml/cm H2O/kg to 0.39 (0.33-0.46) ml/cm H2O/kg; and 24 h: 0.68 (0.36-1.20) ml/cm H2O/kg to 0.36 (0.33-0.55) ml/cm H2O/kg; p < 0.05]. Ventilatory efficiency index and arterial/alveolar ratio significantly improved in caffeine-treated animals over the 24-h study period (p < 0.05, repeated measures ANOVA). CONCLUSIONS: In this pilot study, early caffeine treatment, combined with prophylactic surfactant therapy, was associated with better lung function during the initial 24 h of life. This combined approach may facilitate earlier extubation or prophylactic efforts to support infants on nasal CPAP. Randomized, controlled investigation is warranted.
    [Abstract] [Full Text] [Related] [New Search]