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  • Title: [Roles of mitochondria in vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells].
    Author: Wu K, Li GC, Zhao Y, Zhang XH.
    Journal: Wei Sheng Yan Jiu; 2005 Jan; 34(1):58-60. PubMed ID: 15862025.
    Abstract:
    OBJECTIVE: In order to investigate the roles of mitochondria in vitamin E succinate (VES)-induced apoptosis in human gastric cancer SGC-7901 cells. METHODS: Mitochondrial transmembrane potential (deltapsi(m)) was observed by confocal laser scanning microscopy, while the expression of cytochrome c in cytosol and caspase-3 was measured by western blotting after the cells were treated with VES at 5, 10, 20 microg/ml. RESULTS: VES obviously decreased deltapsi(m) with dose- and time-dependent relationship, increased the expression of cytochrome c in cytosol and caspase-3 and activated caspase-3 as well. CONCLUSION: VES-induced apoptosis in SGC-7901 cells might involve mitochondrial permeability transition, release of cytochrome c and activation of caspase-3 downstream.
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