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  • Title: [Effects of chromium supplementation on IRS-1 expression of skeletal muscle in diabetic rats].
    Author: Sun Z, Wu YT, Che SP, Wang X.
    Journal: Wei Sheng Yan Jiu; 2005 Jan; 34(1):88-91. PubMed ID: 15862035.
    Abstract:
    OBJECTIVE: To study the effects of chromium supplementation on related gene expression to metabolism of skeletal muscles in diabetic rats. METHODS: cDNA fragments from the out related research were cloned, sequenced and its comparalarity analysis has been done. The RT-PCR were made using the primers designed according to the sequence of cDNA. RESULTS: The identities between the sequence of Cr-5 and IRS-1 is 100%. The expression level of DM group (0.791 +/- 0.038) is obviously lower than those of normal group (0.892 +/- 0.053, P < 0.05). And The expression level of DM + Cr group (0.822 +/- 0.066) have some improvement compare to those of DM group (P > 0.05). CONCLUSION: There is a tendency that Chromium supplementation can increase the expression level of IRS-1 mRNA of skeletal muscles in diabetic rats. It will be studied as a candidate gene in future research.
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