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  • Title: The rat retinal ganglion cell in culture: an accessible CNS neurone.
    Author: Lilley S, Robbins J.
    Journal: J Pharmacol Toxicol Methods; 2005; 51(3):209-20. PubMed ID: 15862466.
    Abstract:
    Retinal ganglion cells are vital for vision, some have intrinsic light sensing properties and in retinal networks display complex computational abilities. Furthermore they are implicated in a very common form of blindness, glaucoma as well some the symptoms of AIDS. Retinal ganglion cells, unlike many neurones of the central nervous system, have a clearly defined physiological role and can be identified in primary cultures with ease. Here we detail the cell culture and electrophysiological methods required to obtain recordings on the voltage-gated and ligand-gated ion currents and channels expressed by these neurones. Information is given on the range of non-ionotropic receptors that are thought to be present on these cells and what role they may have as model systems in the pharmacological and pharmaceutical research environment.
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