These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Antiproliferative activity in HL60 cells by tetrasubstituted pyrroles: a structure-activity relationship study.
    Author: Padrón JM, Tejedor D, Santos-Expósito A, García-Tellado F, Martín VS, Villar J.
    Journal: Bioorg Med Chem Lett; 2005 May 16; 15(10):2487-90. PubMed ID: 15863302.
    Abstract:
    A number of tetrasubstituted pyrrole derivatives have been synthesized and evaluated for their in vitro antiproliferative activities using the human promyelocytic leukemia cell line HL60. Tetrasubstituted pyrroles are obtained by irradiation of a silica gel absorbed mixture of a conjugated alkynoate and a primary amine. Active compounds exhibited GI50 values in the range 4-45 microM, and only six products showed TGI values within the evaluation range. A structure-activity relationship is also discussed.
    [Abstract] [Full Text] [Related] [New Search]