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  • Title: The use of biochemical markers in prenatal diagnosis of intrauterine growth retardation: insulin-like growth factor I, Leptin, and alpha-fetoprotein.
    Author: Roig MD, Sabrià J, Valls C, Borràs M, Miró E, Ponce J, Vicens JM.
    Journal: Eur J Obstet Gynecol Reprod Biol; 2005 May 01; 120(1):27-32. PubMed ID: 15866082.
    Abstract:
    OBJECTIVE: To determine the relation between weight deficit at birth and IGF-I, IGFBP-I, Leptin, and AFP levels in amniotic fluid after 14-18 weeks; to assess the diagnostic usefulness of these biochemical markers. STUDY DESIGN: Longitudinal, prospective study. Amniocentesis was performed in pregnant women after 14-18 weeks of gestation. STUDY POPULATION: 86 controls, 18 IUGR <10 percentile, and 17 IUGR <5 percentile. RESULTS: No significant correlation was found between severity of IUGR and IGF-I, IGFBP-I, or Leptin. AFP was inversely correlated with severity of IUGR; results for the IUGR <10 percentile were: S: 65.7%, SP: 56.9%, PPV: 38.3%, NPV: 80.3%, and an overall diagnostic capacity of 65.6%. Results for the IUGR <5 percentile were: S: 76.4%, SP: 54.8%, PPV: 21.6%, NPV: 93.4% were obtained, and an overall capacity of 70.6%. CONCLUSIONS: Elevated values of AFP in amniotic fluid may help early detection of populations at risk of developing IUGR.
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