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  • Title: Interleukin-1 receptor antagonist and interleukin-1 beta polymorphisms in women with recurrent miscarriage.
    Author: Linjawi S, Li TC, Laird S, Blakemore A.
    Journal: Fertil Steril; 2005 May; 83(5):1549-52. PubMed ID: 15866604.
    Abstract:
    Genotypes and allele distributions for the interleukin (IL)-1beta -511 C/T and the IL-1 receptor antagonist gene intron 2 tandem repeat polymorphisms were compared in 206 women with recurrent miscarriage and a control population. No significant differences were observed between the distributions of IL-1beta or IL-1 receptor antagonist gene alleles in either the recurrent miscarriage group as a whole or when divided according to the cause of recurrent miscarriage compared with controls, which suggests that variation in the IL-1 receptor antagonist gene and IL-1beta genes individually does not play a role in susceptibility to recurrent miscarriage.
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