These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Diagnostic evaluation of carbon tetrachloride-induced rat hepatic cirrhosis model.
    Author: Lee GP, Jeong WI, Jeong DH, Do SH, Kim TH, Jeong KS.
    Journal: Anticancer Res; 2005; 25(2A):1029-38. PubMed ID: 15868943.
    Abstract:
    BACKGROUND: To find a non-invasive method of diagnosing hepatic fibrosis and cirrhosis, we evaluated the relationship of the hepatic cirrhosis grade between histopathology and mean grey level (MGL) in B-mode ultrasonography in CCl4-induced liver cirrhosis. MATERIALS AND METHODS: Three groups of rats were treated with olive oil, CCl4, and CCl4 + silymarin. Rats were sacrificed at weeks 4, 8 and 12, after B-mode ultrasonography examination, and then analyzed histopathologically for fatty change and fibrosis. RESULTS: On the grade of fibrosis, the CCl4 group showed higher value at 8 and 12 weeks than the silymarin group. However, the fatty change was enhanced in the silymarin group, compared with the CCl4 group. The B-mode histogram values were the highest in the silymarin group, but the collagen rate was highest in the CCl4-treated group, at week 12. These results suggest that the B-mode histogram can be more affected by infiltration of lipid than by intact accumulation of collagen fibers. CONCLUSION: In the histogram of 8 and 12 weeks, there were significant differences between the CCl4-treated group and silymarin group in mean grey levels of B-mode ultrasonography. The histogram of B-mode mean grey level has a close correlation with fatty change and is useful for the diagnosis of liver fibrosis by histopathological analysis.
    [Abstract] [Full Text] [Related] [New Search]