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  • Title: Restoration of connexin 43 by Bowman-Birk protease inhibitor in M5076 bearing mice.
    Author: Suzuki K, Yano T, Sadzuka Y, Sugiyama T, Seki T, Asano R.
    Journal: Oncol Rep; 2005 Jun; 13(6):1247-50. PubMed ID: 15870950.
    Abstract:
    The present study was designed to investigate the effects of Bowman-Birk inhibitor (BBI) on up-regulation of connexin (Cx) expression to estimate BBI's tumor-suppressor effect in mice with M5076 ovarian sarcoma. The relative tumor weight (p<0.05, r(2)=0.301) and proliferating cell nuclear antigen (PCNA, p<0.01, r(2)=0.493) were negatively correlated with the doses of BBI. In contrast, the relative density of Cx43 was positively correlated with the doses of BBI (p<0.05, r(2)=0.351). Therefore, it suggests that the anti-carcinogenic effects of BBI induced negative growth control caused by the expression of Cx43 genes in mice with M5076 ovarian sarcoma.
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