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  • Title: Clonal spread of pediatric isolates of ciprofloxacin-resistant, emm type 6 Streptococcus pyogenes.
    Author: Alonso R, Mateo E, Galimand M, Garaizar J, Courvalin P, Cisterna R.
    Journal: J Clin Microbiol; 2005 May; 43(5):2492-3. PubMed ID: 15872292.
    Abstract:
    Twenty-four community isolates of Streptococcus pyogenes resistant to ciprofloxacin and susceptible to levofloxacin, gatifloxacin, and moxifloxacin were studied. Sequence determination of the quinolone resistance-determining regions in the gyrA and parC genes revealed a T/G mutation in parC leading to a Ser79Ala substitution in ParC. All isolates were of the emm type 6, and 18 and 2 of them were indistinguishable or closely related, respectively, on the basis of pulsed-field gel electrophoresis.
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