These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A modular approach to polyketide building blocks: cycloadditions of nitrile oxides and homoallylic alcohols.
    Author: Lohse-Fraefel N, Carreira EM.
    Journal: Org Lett; 2005 May 12; 7(10):2011-4. PubMed ID: 15876042.
    Abstract:
    A general approach to the diastereoselective synthesis of Delta(2)-isoxazolines via magnesium-mediated, hydroxyl-directed diastereoselective nitrile oxide cycloadditions of homoallylic alcohols and monoprotected homoallylic diols is disclosed. A broad spectrum of aliphatic and aromatic nitrile oxides and a variety of homoallylic alcohols participate in the cycloaddition, thus expanding the scope of polyketide building blocks that can be accessed using this strategy.
    [Abstract] [Full Text] [Related] [New Search]