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  • Title: An N-acyliminium cyclization approach to a total synthesis of (+)-cylindricine C.
    Author: Liu J, Swidorski JJ, Peters SD, Hsung RP.
    Journal: J Org Chem; 2005 May 13; 70(10):3898-902. PubMed ID: 15876077.
    Abstract:
    [reaction: see text] Details of problems and solutions encountered during the development of an enantioselective total synthesis of (+)-cylindricine C are described here. The total synthesis itself was accomplished in 8 steps, featuring an N-acyliminium cyclization strategy, the seldom-used Wharton rearrangement, and a key epimerization at C5.
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