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  • Title: Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones.
    Author: McDevitt RE, Malamas MS, Manas ES, Unwalla RJ, Xu ZB, Miller CP, Harris HA.
    Journal: Bioorg Med Chem Lett; 2005 Jun 15; 15(12):3137-42. PubMed ID: 15876535.
    Abstract:
    The syntheses of a series of 2-arylindene-1-ones as potent ligands of ERbeta and ERalpha are described. Several compounds exhibited high potency and moderate selectivity for the ERbeta receptor. X-ray and modeling studies were used to understand ligand binding orientation and observed affinity.
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