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  • Title: Preparation of a fully substituted purine library.
    Author: Yang J, Dang Q, Liu J, Wei Z, Wu J, Bai X.
    Journal: J Comb Chem; 2005; 7(3):474-82. PubMed ID: 15877476.
    Abstract:
    A library of tetra-substituted purine analogues was readily prepared via parallel synthesis. This strategy relies on a key cyclization of a 4,5-diaminopyrimidine with either a carboxylic acid or its derivative to construct the 2,8,9-trisubstituted 6-chloropurine core. Further elaborations of this core allow the introduction of other diversity points. This methodology is demonstrated through the preparation of a 135-membered library of tetra-substituted purines in good yields and high purity.
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