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  • Title: Formation of 4-aminopyrimidines via the trimerization of nitriles using focused microwave heating.
    Author: Baxendale IR, Ley SV.
    Journal: J Comb Chem; 2005; 7(3):483-9. PubMed ID: 15877477.
    Abstract:
    A series of substituted aliphatic nitriles have been trimerized to their corresponding pyrimidine structures under solvent-free conditions in the presence of catalytic quantities of potassium tert-butoxide using a focused microwave reactor. Multigram quantities of the corresponding 4-aminopyrimidines have been prepared in high yields and purity following a simple and scaleable protocol.
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