These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


PUBMED FOR HANDHELDS

Search MEDLINE/PubMed


  • Title: [Expression of heat shock protein 70 in intestinal mucosa during the early stage after severe burns and its significance].
    Author: Yuan ZQ, Peng YZ, Li XL, Huang YS, Yang ZC.
    Journal: Zhongguo Wei Zhong Bing Ji Jiu Yi Xue; 2005 May; 17(5):264-7. PubMed ID: 15877948.
    Abstract:
    OBJECTIVE: To study the expression of heat shock protein 70 (HSP70) in intestinal mucosa during the early stage after severe burn injury and its significance. METHODS: With a model of 30% total body surface area (TBSA) full-thickness burned rats, the expression and distribution of HSP70 and heat shock factor-1 (HSF1) in intestinal mucosal were determined by reverse transcription-polymerase chain reaction (RT-PCR), Western blot and immunohistochemistry at 3, 6, 12, 24 and 48 hours postburn. RESULTS: The expression of HSP70 mRNA and protein in intestinal mucosa increased markedly at 3 hours after severe burns, peaked at 6 and 12 hours, and lasted for 48 hours postburn (all P<0.01). Following a slight decline at 3 hours postburn, the expression of HSF1 increased gradually, and reached a highest level at 48 hours postburn (all P<0.01). CONCLUSION: The expression of HSP70 and HSF1 markedly increase in intestinal mucosa following severe burn injury. It is suggested that the self-protective mechanism of cells might explain the increase of HSP70 expression.
    [Abstract] [Full Text] [Related] [New Search]