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  • Title: Discoid lupus erythematosus masquerading as chronic blepharoconjunctivitis.
    Author: Acharya N, Pineda R, Uy HS, Foster CS.
    Journal: Ophthalmology; 2005 May; 112(5):e19-23. PubMed ID: 15878050.
    Abstract:
    PURPOSE: To recognize discoid lupus erythematosus (DLE) as a treatable cause of chronic blepharoconjunctivitis. DESIGN: Retrospective observational case series. PARTICIPANTS: Records of 5 patients with biopsy-proven DLE were reviewed. METHODS: Clinical and pathology records were examined. MAIN OUTCOME MEASURES: Patients' clinical and histopathological characteristics and response to treatment were assessed. RESULTS: Clinical features included meibomian gland dysfunction, blepharitis, chalazia, trichiasis, madarosis, conjunctivitis, chronic eyelid edema, and eyelid plaques. Histopathology showed hyperkeratotic epithelium, degeneration of the basal cell layer, and a perivascular lymphocytic infiltrate. There was delayed diagnosis in all cases, ranging from 4 months to 25 years. All of the patients responded to systemic hydroxychloroquine therapy. CONCLUSIONS: Heightened awareness of eyelid DLE may lead to earlier detection and specific therapy for this chronic disorder.
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