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  • Title: Effectiveness and toxicity of single-fraction radiotherapy with 1 x 8 Gy for metastatic spinal cord compression.
    Author: Rades D, Stalpers LJ, Hulshof MC, Zschenker O, Alberti W, Koning CC.
    Journal: Radiother Oncol; 2005 Apr; 75(1):70-3. PubMed ID: 15878103.
    Abstract:
    Toxicity and functional outcome were evaluated in 199 MSCC-patients irradiated with 1 x 8 Gy. Motor function improved in 54/199 patients (27%). Patients who regained walking ability were 20/78 (26%). Long-term-survivors (> or =12 months) who needed re-irradiation for in-field-recurrence were 19/65 (29%). Acute toxicity was mild, late toxicity not observed. A randomised trial comparing single-fraction RT to multi-fraction RT is mandatory.
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