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  • Title: Finnish efficacy trials with Haemophilus influenzae type b vaccines.
    Author: Eskola J, Peltola H, Käyhty H, Takala AK, Mäkelä PH.
    Journal: J Infect Dis; 1992 Jun; 165 Suppl 1():S137-8. PubMed ID: 1588148.
    Abstract:
    The first Finnish trial with Haemophilus influenzae type b vaccine was conducted during 1973-1974. It demonstrated that the polysaccharide vaccine was 90% efficacious in children greater than or equal to 18-24 months old. The immunologically superior polysaccharide-protein conjugate vaccines have been used since 1986 in randomized trials. The PRP-D vaccine (polysaccharide conjugated to diphtheria toxoid) was 90% efficacious when given at 3, 4, and 6 months of age to 58,000 infants. In 1988-1989, the PRP-D vaccine was compared with the HbOC vaccine (oligosaccharide conjugated to CRM197 protein). Follow-up is continuing, but both vaccines seem to be efficacious after two doses in infancy.
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