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  • Title: [An open study on the efficacy and tolerability of quetiapine treatment of patients with schizophrenia].
    Author: Beszłej JA, Grzesiak M.
    Journal: Psychiatr Pol; 2005; 39(2):293-307. PubMed ID: 15881624.
    Abstract:
    AIM: Assessment of efficacy and tolerability of quetiapine in treatment of schizophrenia. METHOD: Patients with a diagnosis of schizophrenia (according to ICD-10, DSM-IV) were included in the 12-weeks open study. Severity of schizophrenia symptoms was evaluated using the PANSS Scale. Adverse events have been assessed according to The Adverse Events Inventory, The Simpson Angus Extrapyramidal Symptoms Scale, the Akathisia Barnes Scale and the Involuntary Movement Scale. Quetiapine has been used in increasing doses up to 600 mg/day. RESULTS: Thirty-eight persons were included. The total scores in PANSS before treatment were 84.7 on average. Twenty-eight patients (74%) completed the study. Reduction in severity of schizophrenia according to the PANSS Scale was statistically significant (p < 0.01). Reduction of scores in the range 20-29% was obtained in 18 patients (48.6%), 30-39% in 10 patients (26.3%) and above 40% in 2 patients (5.4%). Adverse symptoms occurred in 71% patients. The most common were: drowsiness (18%), weakness (10.5%), restlessness (10.5%), agitation (10.5%) and increase in severity of delusions and hallucinations (10.5%). CONCLUSION: In the study, Quetiapine caused the reduction in the positive and negative symptoms of schizophrenia. Serious adverse events requiring drop-out of the study were not observed. The severity of extrapyramidal symptoms with statistical significance decreased during the quetiapine treatment (p < 0.05).
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