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  • Title: Protective effect of curcumin during selenium induced toxicity on dehydrogenases in hepatic tissue.
    Author: Padmaja S, Raju TN.
    Journal: Indian J Physiol Pharmacol; 2005 Jan; 49(1):111-4. PubMed ID: 15881869.
    Abstract:
    Selenium administration resulted in a marked decrease in the activity levels of the liver succinate dehydrogenase, malate dehydrogenase, and lactate dehydrogenase while pyruvate dehydrogenase increased significantly (P<0.001) in the wistar rat. The degree of decrease of these enzymes was significantly less (P<0.001) when rats were treated with curcumin, a natural constituent Curcuma longa. Curcumin seems to prevent oxidative damage mediated through selenium and protect the dehydrogenases possibly through its anti-oxidative property.
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