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  • Title: Novel thiazolidine-2,4-diones as potent euglycemic agents.
    Author: Hulin B, Clark DA, Goldstein SW, McDermott RE, Dambek PJ, Kappeler WH, Lamphere CH, Lewis DM, Rizzi JP.
    Journal: J Med Chem; 1992 May 15; 35(10):1853-64. PubMed ID: 1588563.
    Abstract:
    A new series of thiazolidine-2,4-diones was obtained by replacing the ether function of englitazone with various functional groups, i.e., a ketone, alcohol, or olefin moiety. These compounds lower blood glucose levels in the genetically obese and insulin-resistant ob/ob mouse. Appending an oxazole-based group at the terminus of the chain provided highly potent compounds.
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