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  • Title: Dissection of human tropoelastin: supramolecular organization of polypeptide sequences coded by particular exons.
    Author: Pepe A, Guerra D, Bochicchio B, Quaglino D, Gheduzzi D, Pasquali Ronchetti I, Tamburro AM.
    Journal: Matrix Biol; 2005 Apr; 24(2):96-109. PubMed ID: 15890261.
    Abstract:
    Polypeptide sequences encoded by some exons of the human tropoelastin gene (EDP, elastin-derived peptide) have been analysed for their ability to coacervate and to self-assembly. The great majority of them were shown to form organized structures, but only a few were indeed able to coacervate. Negative staining and rotary shadowing transmission electron microscopy showed the polypeptides to adopt a variety of supramolecular organization, from filaments, as those typical of tropoelastin, to amyloid-like fibers. The results obtained gave significant insight to the possible roles played by specific polypeptide sequences of tropoelastin.
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