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  • Title: Structure and function of the notochord: an essential organ for chordate development.
    Author: Stemple DL.
    Journal: Development; 2005 Jun; 132(11):2503-12. PubMed ID: 15890825.
    Abstract:
    The notochord is the defining structure of the chordates, and has essential roles in vertebrate development. It serves as a source of midline signals that pattern surrounding tissues and as a major skeletal element of the developing embryo. Genetic and embryological studies over the past decade have informed us about the development and function of the notochord. In this review, I discuss the embryonic origin, signalling roles and ultimate fate of the notochord, with an emphasis on structural aspects of notochord biology.
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