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  • Title: Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals.
    Author: Chartrel N, Bruzzone F, Dujardin C, Leprince J, Tollemer H, Anouar Y, Vallarino M, Costentin J, Vaudry H.
    Journal: Ann N Y Acad Sci; 2005 Apr; 1040():80-3. PubMed ID: 15891009.
    Abstract:
    In the present study, we report the identification, in the frog brain, of a novel neuropeptide, termed 26RFa, that belongs to the RFamide peptide family. The cDNAs encoding the precursors for 26RFa have been characterized in human and rats. In rats, prepro-26RFa mRNA is expressed exclusively in two hypothalamic nuclei involved in the control of feeding behavior. Intracerebroventricular injection of 26RFa in mice induced a dose-dependent increase in food consumption. Taken together, these data indicate that 26RFa is a novel neuropeptide that may have important biological functions in vertebrates.
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