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  • Title: Endothelin-3 stimulates the release of catecholamine from cortical and striatal slices of the rat.
    Author: Koizumi S, Kataoka Y, Niwa M, Kumakura K.
    Journal: Neurosci Lett; 1992 Jan 06; 134(2):219-22. PubMed ID: 1589148.
    Abstract:
    Endothelin-3 (ET-3) evoked the release of dopamine/noradrenaline from cortical slices and dopamine from striatal slices in a concentration-dependent manner. This action peaked slowly and was long-lasting in real-time monitoring, being different from the high K(+)-evoked response. The striatal response to 10 microM of ET-3 was reduced by extracellular Ca2+ depletion to 40% of control and by Ca2+ antagonists, especially nifedipine and flunarizine, to 40% of control. Our findings suggest that ET has a physiological significance in the brain as a neuromodulator for catecholaminergic transmission.
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