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  • Title: Proton magnetic resonance spectroscopy and diffusion-weighted imaging of central nervous system whipple disease.
    Author: Nelson JW, White ML, Zhang Y, Moritani T.
    Journal: J Comput Assist Tomogr; 2005; 29(3):320-2. PubMed ID: 15891498.
    Abstract:
    A 72-year-old man presented with a 6-month history of dysphagia, fatigue, 60-lb weight loss, and central nervous system (CNS) deficits. Diffusion-weighted magnetic resonance imaging (MRI) of the brain showed mildly elevated nonrestricted apparent diffusion coefficients in the middle cerebellar peduncles, and magnetic resonance spectroscopy (MRS) showed decreased N-acetylaspartate and creatine with increased choline. Diffusion-weighted MRI and MRS offer noninvasive methods to help evaluate in vivo physiologic changes of CNS involvement in Whipple disease.
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