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  • Title: Short-term repeatability of electrocardiographic spatial T-wave axis and QT interval.
    Author: Vaidean GD, Schroeder EB, Whitsel EA, Prineas RJ, Chambless LE, Perhac JS, Heiss G, Rautaharju PM.
    Journal: J Electrocardiol; 2005 Apr; 38(2):139-47. PubMed ID: 15892024.
    Abstract:
    Although ventricular repolarization abnormalities reflect arrhythmic susceptibility, few reliable tools exist to identify their presence. We investigated the repeatability of the spatial T-wave axis and QT interval from standard 12-lead electrocardiograms in 63 asymptomatic volunteers. Certified technicians used a standardized protocol to digitally record 2 electrocardiograms per participant at each of 2 visits separated by 1 to 2 weeks. Absolute paired differences within and between visits were 0.19 degrees and 0.90 degrees for the T-wave axis and 1.08 and 1.55 milliseconds for the QT interval, respectively. The intraclass correlation coefficients for the T-wave axis and QT interval were 0.87 and 0.86, respectively. The impact of repeated measurements on the precision of the QT-interval measurements was evaluated for a hypothetical clinical trial aimed at detecting a drug-induced QT prolongation. We conclude that the spatial T-wave axis is as repeatable a measure of ventricular repolarization as the QT interval.
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