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  • Title: Synthesis and antifungal activity of 2/3-arylthio- and 2,3-bis(arylthio)-5-hydroxy-/5-methoxy-1,4-naphthoquinones.
    Author: Ryu CK, Shim JY, Chae MJ, Choi IH, Han JY, Jung OJ, Lee JY, Jeong SH.
    Journal: Eur J Med Chem; 2005 May; 40(5):438-44. PubMed ID: 15893017.
    Abstract:
    2/3-Arylthio- and 2,3-bis(arylthio)-5-hydroxy-/5-methoxy-1,4-naphthoquinones 5-9 were synthesized and tested for in vitro antifungal activity against Candida species and Aspergillus niger. The synthesized compounds 5-9 generally showed good activities against Candida albicans and C. tropicalis. The results suggest that the 1,4-naphthoquinones 5-9 would be potent antifungal agents.
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