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  • Title: Fecal Adnab-9 binding as a risk marker for colorectal neoplasia.
    Author: Yuan M, Xhang X, Leu Y, Xu Y, Ullah N, Lawson M, Tobi M.
    Journal: Cancer Lett; 2006 Apr 08; 235(1):48-52. PubMed ID: 15893419.
    Abstract:
    Adnab-9 binding in colonic tissue and effluent has been associated with an increased risk for colorectal neoplasia. We investigated if fecal binding by Adnab-9 may be used as a marker for colorectal neoplasia. A fecal-Adnab-9 ELISA was performed on samples of 249 patients and colonoscopic pathology results correlated. Fecal Adnab-9 binding was seen in 63% of patients with colorectal neoplasia (59% with colorectal cancer and 83% with adenoma), 33% with inflammatory bowel disease, 0% with hyperplastic polyps and 10% of controls. We conclude that fecal Adnab-9 binding is a promising risk marker for colorectal neoplasia.
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