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  • Title: Peroxidases: a role in the metabolism and side effects of drugs.
    Author: Tafazoli S, O'Brien PJ.
    Journal: Drug Discov Today; 2005 May 01; 10(9):617-25. PubMed ID: 15894226.
    Abstract:
    Current safety screening of drug candidates or new chemical entities for reactive metabolite formation focuses on the role of cytochrome P450. However, peroxidases also have a major role in drug metabolism, and peroxidase-catalyzed drug oxidation could lead to reactive metabolite formation, resulting in oxidative stress and cytotoxicity. Here, the different classes of human peroxidases are summarized and the molecular mechanisms of peroxidase-catalyzed drug metabolism are discussed. In addition, evidence is presented that indicates a role of these enzymes in drug toxicity.
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