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  • Title: Repeated-batch production of kojic acid in a cell-retention fermenter using Aspergillus oryzae M3B9.
    Author: Wan HM, Chen CC, Giridhar R, Chang TS, Wu WT.
    Journal: J Ind Microbiol Biotechnol; 2005 Jun; 32(6):227-33. PubMed ID: 15895266.
    Abstract:
    A cell-retention fermenter was used for the pilot-scale production of kojic acid using an improved strain of Aspergillus oryzae in repeated-batch fermentations. Among the various carbon and nitrogen sources used, sucrose and yeast extract promoted pellet morphology of fungi and higher kojic acid production. Repeated-batch culture using a medium replacement ratio of 75% gave a productivity of 5.3 gL(-1)day(-1) after 11.5 days of cultivation. While batch culture in shake-flasks resulted in a productivity of 5.1 gL(-1)day(-1), a productivity of 5 gL(-1)day(-1) was obtained in a pilot-scale fermenter. By converting the batch culture into repeated batches, the non-productive downtime of cleaning, filling and sterilizing the fermenter between each batch were eliminated, thereby increasing the kojic acid productivity.
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