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  • Title: Nitrone derivatives of trolox as neuroprotective agents.
    Author: Balogh GT, Vukics K, Könczöl A, Kis-Varga A, Gere A, Fischer J.
    Journal: Bioorg Med Chem Lett; 2005 Jun 15; 15(12):3012-5. PubMed ID: 15896960.
    Abstract:
    Synthesis of nitrone derivatives of trolox is described. Their biological evaluation was performed in vitro for scavenging different free radicals, inhibiting Fe(2+)-induced lipid peroxidation, and in vivo in a permanent middle cerebral artery occlusion model in mice. New compounds exert pharmacological activities comparable to or better than those of trolox or nitrone-type reference compounds.
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