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  • Title: Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists.
    Author: Wang X, Bhatia PA, Daanen JF, Latsaw SP, Rohde J, Kolasa T, Hakeem AA, Matulenko MA, Nakane M, Uchic ME, Miller LN, Chang R, Moreland RB, Brioni JD, Stewart AO.
    Journal: Bioorg Med Chem; 2005 Aug 01; 13(15):4667-78. PubMed ID: 15896964.
    Abstract:
    A series of 3-aryl piperidine analogs with 2-piperidinoalkylamino or 2-piperidinoalkyloxy fused bicyclic rings were prepared and found to be potent and efficacious human dopamine D4 agonists. The synthesis and structure-activity relationship (SAR) studies that led to the identification of these compounds are discussed.
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