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  • Title: Synthesis of 2,4,6-trisubstituted pyrimidines as antimalarial agents.
    Author: Agarwal A, Srivastava K, Puri SK, Chauhan PM.
    Journal: Bioorg Med Chem; 2005 Aug 01; 13(15):4645-50. PubMed ID: 15896965.
    Abstract:
    A series of 2,4,6-trisubstituted-pyrimidines were synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Of the 18 compounds synthesized, 14 compounds have shown MIC in the range of 0.25-2 microg/mL. These compounds are in vitro severalfold more active than pyrimethamine.
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