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  • Title: [Pharmacological treatment in severe dementia].
    Author: Jouanny P, Belliard S, Bentué-Ferrer D, Michel O, Allain H.
    Journal: Psychol Neuropsychiatr Vieil; 2005 Mar; 3 Suppl 1():S51-5. PubMed ID: 15899605.
    Abstract:
    Medical treatment of severe dementia is now available. Decrease of psychobehavioral disturbances, autonomy loss or care-giver burden appear as the main objective rather than reduction of cognitive deficits. Acetylcholinesterase inhibitors (AChE-I) should be maintained in patients with severe dementia when initiated in mild or moderate dementia. Memantine is the specific treatment for patients with severe dementia, even if they received AChE-I. To treat the psychobehavioral disturbancies, serotoninergic agents and thymoregulators are the first line drugs. Medical treatment should only be co-prescribed with a global care of all co-morbidities, autonomy loss and patient's and care-giver's burden, and associated with psychological and organisational support.
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