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  • Title: Stereoselective hydroxylation of an achiral cyclopentanecarboxylic acid derivative using engineered P450s BM-3.
    Author: Münzer DF, Meinhold P, Peters MW, Feichtenhofer S, Griengl H, Arnold FH, Glieder A, de Raadt A.
    Journal: Chem Commun (Camb); 2005 May 28; (20):2597-9. PubMed ID: 15900339.
    Abstract:
    Substrate engineered, achiral carboxylic acid derivative was biohydroxylated with various mutants of cytochrome P450 BM-3 to give two out of the four possible diastereoisomers in high de and ee. The BM-3 mutants exhibit up to 9200 total turnovers for hydroxylation of the engineered substrate, which without the protecting group is not transformed by this enzyme.
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