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  • Title: Lancifodilactone G: a unique nortriterpenoid isolated from Schisandra lancifolia and its anti-HIV activity.
    Author: Xiao WL, Zhu HJ, Shen YH, Li RT, Li SH, Sun HD, Zheng YT, Wang RR, Lu Y, Wang C, Zheng QT.
    Journal: Org Lett; 2005 May 26; 7(11):2145-8. PubMed ID: 15901155.
    Abstract:
    [structure: see text]. Lancifodilactone G (1), a novel, highly oxygenated nortriterpenoid featuring a partial enol structure and a spirocyclic moiety, was isolated from the medicinal plant Schisandra lancifolia. Its structure and stereochemistry were determined from extensive one- and two-dimensional NMR and mass spectral data, coupled with single-crystal X-ray analysis. Compound 1 exerted minimal cytotoxicity against C8166 cells (CC50 > 200 microg/mL) and showed anti-HIV activity with EC50 = 95.47 +/- 14.19 microg/mL and a selectivity index in the range of 1.82-2.46.
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