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  • Title: Synthesis of the C12-C19 fragment of (+)-peloruside A through a diastereomer-discriminating RCM reaction.
    Author: Roulland E, Ermolenko MS.
    Journal: Org Lett; 2005 May 26; 7(11):2225-8. PubMed ID: 15901175.
    Abstract:
    [reaction: see text]. A short and efficient asymmetric synthesis of the C12-C19 fragment of the cytotoxic macrolide (+)-peloruside A has been achieved via a highly diastereomer-discriminating RCM of alpha-branched but-3-enoate ester of a methallylic alcohol derived from hydrolytically resolved (S)-(-)-propylene oxide.
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