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  • Title: Progestin-facilitated lordosis of hamsters may involve dopamine-like type 1 receptors in the ventral tegmental area.
    Author: Sumida K, Walf AA, Frye CA.
    Journal: Behav Brain Res; 2005 Jun 03; 161(1):1-7. PubMed ID: 15904704.
    Abstract:
    Hamsters are highly-dependent upon the central actions of progesterone (P) to facilitate sexual behavior. P has membrane mechanisms of action in the ventral tegmental area (VTA) to facilitate sexual receptivity of rodents. The present experiments examined whether P's membrane actions in the VTA include dopamine (DA) type 1 (D(1)) or dopamine type 2 (D(2)) receptors. Ovariectomized (ovx), estradiol (E(2))- and P-primed hamsters were infused with D(1) (Experiment 1) or D(2) (Experiment 2) antagonists or agonists (0 or 100 ng) to the VTA and tested 30 min later. The D(1) agonist, SKF38393, enhanced P-facilitated lordosis. The D(1) antagonist, SCH23390, attenuated P-facilitated lordosis. The D(2) agonist, quinpirole and the D(2) antagonist, sulpiride, had no significant effects on P-facilitated lordosis. These data suggest that, in hamsters, P's actions for lordosis may involve D(1) receptors in the VTA.
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