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  • Title: Application of GC-EI-MS for the identification and investigation of positional isomer in primaquine, an antimalarial drug.
    Author: Dongre VG, Karmuse PP, Nimbalkar MM, Singh D, Kumar A.
    Journal: J Pharm Biomed Anal; 2005 Sep 01; 39(1-2):111-6. PubMed ID: 15905064.
    Abstract:
    A major impurity associated with primaquine drug samples obtained from European Pharmacopoeia (EP) and other commercial sources was detected and identified using HPLC, photo diode array (PDA), LC-MS/MS and gas chromatograph-electron impact-mass spectrometer (GC-EI-MS). PDA and LC-ESI-MS/MS data provided an evidence for it being isomeric in nature. However, spectral data obtained from the newly developed GC-EI-MS method has been utilised for structural elucidation and found to be conclusive to characterize this impurity as positional isomer, i.e. 8-(4-amino-4-methylbutyl amino)-6 methoxyquinoline. The structure of this impurity has been confirmed by its synthesis. Precursor of primaquine was also investigated using GC-EI-MS. The data obtained confirmed the origin of isomeric impurity in precursor.
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