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  • Title: Dose minimization study of oxytocin in early labor in sows: uterine activity and fetal outcome.
    Author: Mota-Rojas D, Nava-Ocampo AA, Trujillo ME, Velázquez-Armenta Y, Ramírez-Necoechea R, Martínez-Burnes J, Alonso-Spilsbury YM.
    Journal: Reprod Toxicol; 2005; 20(2):255-9. PubMed ID: 15907661.
    Abstract:
    Two hundred sows were randomly assigned to intramuscularly receive 0.9% NaCl (group 1) or oxytocin 0.083, 0.11 or 0.17 IU/kg (groups 2, 3 and 4, respectively) immediately after the expulsion of the first piglet. The overall duration of labor was decreased in a dose-dependent relationship. Time interval between piglets was decreased approximately 5 min in groups 3 and 4 while sows in these groups exhibited approximately 10-20 contractions x 10 births more than controls (P<0.005). Duration and intensity of uterine contractions also showed a positive dose-response relationship. As an indicative of fetal distress, approximately 2.5 times more meconium-stained piglets were born to sows receiving the higher doses of oxytocin, but in the lowest dose significantly decreased. Oxytocin 0.083 IU/kg significant decreased the mortality rate of piglets [OR 0.49 (95%CI, 0.26-0.92)]. In conclusion, we recommend the intramuscular administration of the lowest possible dose of oxytocin, which still decreases the duration of labor in sows.
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