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  • Title: The third molecule associated with interleukin 2 receptor alpha and beta chain.
    Author: Kamio M, Arima N, Tsudo M, Imada K, Ohkuma M, Uchiyama T.
    Journal: Biochem Biophys Res Commun; 1992 May 15; 184(3):1288-92. PubMed ID: 1590791.
    Abstract:
    It is known that the affinity cross-linking study of the human high-affinity Interleukin 2 (IL-2) receptor reveals triplet bands consisting of 70 kDa alpha chain(Tac)-IL-2 and the 90/80 kDa doublet. We found the cell lines lacking the lower band of the doublet in spite of the expression of both alpha and beta chains. No IL-2 binding was detectable in the presence of anti-Tac antibody in these cells. Immunoprecipitation from the cell extract of [125 I] IL-2-cross-linked T cells with anti-beta chain polyclonal IgG detected the upper band, but not lower band of the doublet. These data suggest that the lower band of the doublet represents an unknown IL-2-binding protein (p65) distinct from the beta chain and this molecule may be involved in the intermediate-affinity IL-2 binding together with the beta chain.
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